Updates on immunologic correlates of vaccine-induced protection

Stanley A Plotkin

doi:10.1016/j.vaccine.2019.10.046

Updates on immunologic correlates of vaccine-induced protection

Vaccine. 2020 Feb 24;38(9):2250-2257. doi: 10.1016/j.vaccine.2019.10.046. Epub 2019 Nov 22.

Author

Stanley A Plotkin¹

Affiliation

¹ Emeritus Professor of Pediatrics, University of Pennsylvania, Vaxconsult, 4650 Wismer Rd., Doylestown, PA 18902, United States. Electronic address: Stanley.plotkin@vaxconsult.com.

PMID: 31767462
DOI: 10.1016/j.vaccine.2019.10.046

Abstract

Correlates of protection (CoPs) are increasingly important in the development and licensure of vaccines. Although the study of CoPs was initially directed at identifying a single immune function that could explain vaccine efficacy, it has become increasingly clear that there are often multiple functions responsible for efficacy. This review is meant to supplement prior articles on the subject, illustrating both simple and complex CoPs.

Keywords: Antibodies; Cell mediated immunity; Correlates.

Publication types

Review

MeSH terms

Communicable Disease Control*
Communicable Diseases / immunology*
Humans
Vaccines / immunology*

Substances

Vaccines